Modulation of the feeding response to peripheral insulin, 2-deoxyglucose or 3-0-methyl glucose injection

Booth, D A (1972) Modulation of the feeding response to peripheral insulin, 2-deoxyglucose or 3-0-methyl glucose injection. Physiology and Behavior, 8 (6). pp. 1069-1076. ISSN 0031-9384

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Abstract

The effects of circadian rhythm, delayed access to food, bilateral subdiaphragmatic vagotomy and bilateral adrenal medullectomy were examined. Like normal insulin injected subcutaneously, 2-deoxy-D-glucose injected intraperitoneally induces feeding in sated rats by night as well as by day. The unmetabolized glucose analogue 3-O-methyl-D-glucopyranose detectably increases feeding by day. On delayed return of food after 2-deoxyglucose injection into mildly deprived rats, feeding is at first inhibited and then facilitated. Vagotomy but not medullectomy interferes with 2-deoxyglucose-induced feeding, whereas medullectomy but not vagotomy interferes with insulin-induced feeding, when dosages near the optima for intact rats are used. However, when low doses are given, neither surgically induced deficit is evident.

Item Type: Article
Schools and Departments: School of Psychology > Psychology
Subjects: Q Science > QP Physiology > QP0501 Animal biochemistry
Q Science > QZ Psychology
Depositing User: prof. David Booth
Date Deposited: 01 Mar 2015 11:14
Last Modified: 24 Apr 2015 14:32
URI: http://sro.sussex.ac.uk/id/eprint/53122
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