Clinical and pharmacogenomic implications of genetic variation in a Southern Ethiopian population

Tekola-Ayele, F, Adeyemo, A, Aseffa, A, Hailu, E, Finan, C, Davey, G, Rotimi, C N and Newport, M J (2015) Clinical and pharmacogenomic implications of genetic variation in a Southern Ethiopian population. Pharmacogenomics Journal, 15 (1). pp. 101-108. ISSN 1470-269X

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Abstract

Africa is home to genetically diverse human populations. We compared the genetic structure of the Wolaita ethnic population from Southern Ethiopia (WETH, n=120) with HapMap populations using genome-wide variants. We investigated allele frequencies of 443 clinically and pharmacogenomically relevant genetic variants in WETH compared with HapMap populations. We found that WETH were genetically most similar to the Kenya Maasai and least similar to the Japanese in HapMap. Variant alleles associated with increased risk of adverse reactions to drugs used for treating tuberculosis (rs1799929 and rs1495741 in NAT2), thromboembolism (rs7294, rs9923231 and rs9934438 in VKORC1), and HIV/AIDS and solid tumors (rs2242046 in SLC28A1) had significantly higher frequencies in WETH compared with African ancestry HapMap populations. Our results illustrate that clinically relevant pharmacogenomic loci display allele frequency differences among African populations. We conclude that drug dosage guidelines for important global health diseases should be validated in genetically diverse African populations.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Global Health and Infection
Depositing User: Gharib Murbe
Date Deposited: 19 Feb 2015 13:03
Last Modified: 02 Aug 2017 16:38
URI: http://sro.sussex.ac.uk/id/eprint/53005
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