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Assembly and trafficking of P2X purinergic receptors (review)

journal contribution
posted on 2023-06-08, 19:52 authored by Ruth Murrell-LagnadoRuth Murrell-Lagnado, Omar S Qureshi
P2X receptors are cation selective ion channels gated by the binding of extracellular ATP. Seven subtypes have been identified and they have widespread and overlapping distributions throughout the body. They form homo- and heterotrimeric complexes that differ in their functional properties and subcellular localization. They form part of larger signalling complexes, interacting with unrelated ion channels and other membrane and cytosolic proteins. Up- or down-regulation of their expression is associated with several disease states. This review aims to summarize recent work on the assembly and trafficking of this family of receptors.

History

Publication status

  • Published

Journal

Molecular Membrane Biology

ISSN

0968-7688

Publisher

Taylor & Francis

Issue

4

Volume

25

Page range

321-331

Department affiliated with

  • Biochemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2015-03-25

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