Assembly and trafficking of P2X purinergic receptors (review)

Murrell-Lagnado, Ruth D and Qureshi, Omar S (2008) Assembly and trafficking of P2X purinergic receptors (review). Molecular Membrane Biology, 25 (4). pp. 321-331. ISSN 0968-7688

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Abstract

P2X receptors are cation selective ion channels gated by the binding of extracellular ATP. Seven subtypes have been identified and they have widespread and overlapping distributions throughout the body. They form homo- and heterotrimeric complexes that differ in their functional properties and subcellular localization. They form part of larger signalling complexes, interacting with unrelated ion channels and other membrane and cytosolic proteins. Up- or down-regulation of their expression is associated with several disease states. This review aims to summarize recent work on the assembly and trafficking of this family of receptors.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
Subjects: Q Science > QH Natural history > QH0301 Biology
Depositing User: Tom Gittoes
Date Deposited: 25 Mar 2015 13:43
Last Modified: 25 Mar 2015 13:43
URI: http://sro.sussex.ac.uk/id/eprint/52602
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