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P2X4 receptors interact with both P2X2 and P2X7 receptors in the form of homotrimers
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posted on 2023-06-08, 19:52 authored by L S Antonio, A P Stewart, X J Xu, W A Varanda, Ruth Murrell-LagnadoRuth Murrell-Lagnado, J M EdwardsonThe P2X receptor family consists of seven subunit types - P2X1-P2X7. All but P2X6 are able to assemble as homotrimers. In addition, various subunit permutations have been reported to form heterotrimers. Evidence for heterotrimer formation includes co-localization, co-immunoprecipitation and the generation of receptors with novel functional properties; however, direct structural evidence for heteromer formation, such as chemical cross-linking and single-molecule imaging, is available in only a few cases. Here we examined the nature of the interaction between two pairs of subunits - P2X2 and P2X4, and P2X4 and P2X7.
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Publication status
- Published
Journal
British Journal of PharmacologyISSN
0007-1188Publisher
Nature Publishing GroupExternal DOI
Issue
5Volume
163Page range
1069-1077Department affiliated with
- Biochemistry Publications
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- No
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- Yes
Legacy Posted Date
2015-03-25Usage metrics
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