P2X4 receptors interact with both P2X2 and P2X7 receptors in the form of homotrimers

Antonio, L S, Stewart, A P, Xu, X J, Varanda, W A, Murrell-Lagnado, R D and Edwardson, J M (2011) P2X4 receptors interact with both P2X2 and P2X7 receptors in the form of homotrimers. British Journal of Pharmacology, 163 (5). pp. 1069-1077. ISSN 0007-1188

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Abstract

The P2X receptor family consists of seven subunit types - P2X1-P2X7. All but P2X6 are able to assemble as homotrimers. In addition, various subunit permutations have been reported to form heterotrimers. Evidence for heterotrimer formation includes co-localization, co-immunoprecipitation and the generation of receptors with novel functional properties; however, direct structural evidence for heteromer formation, such as chemical cross-linking and single-molecule imaging, is available in only a few cases. Here we examined the nature of the interaction between two pairs of subunits - P2X2 and P2X4, and P2X4 and P2X7.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
Subjects: Q Science > QH Natural history > QH0301 Biology
Depositing User: Tom Gittoes
Date Deposited: 25 Mar 2015 13:31
Last Modified: 25 Mar 2015 13:31
URI: http://sro.sussex.ac.uk/id/eprint/52592
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