AFM imaging reveals the assembly of a P2X receptor complex containing P2X2, P2X4 and P2X6 subunits

Antonio, Ligia S, Stewart, Andrew P, Varanda, Wamberto A, Murrell-Lagnado, Ruth and Edwardson, J Michael (2012) AFM imaging reveals the assembly of a P2X receptor complex containing P2X2, P2X4 and P2X6 subunits. The Journal of Biological Chemistry, 102 (3S1). 336a-336s. ISSN 0021-9258

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Abstract

Seven P2X purinergic receptor subunits have been identified: P2X1-P2X7. All except P2X6 assemble as homotrimers, and six heteromeric receptors (P2X1/2, P2X1/4, P2X1/5, P2X2/3, P2X2/6 and P2X4/6) have been described. In addition, P2X4 homomers associate with P2X2 or P2X7 homomers as dimers of trimers. The various P2X receptors show individual functional properties, suggesting distinct physiological roles. The overlapping expression of P2X2, P2X4 and P2X6 subunits has been shown in different cell types, and functional analysis of P2X receptors in Leydig cells suggests that the three subunits interact.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
Subjects: Q Science > QH Natural history > QH0301 Biology
Depositing User: Tom Gittoes
Date Deposited: 25 Mar 2015 13:55
Last Modified: 08 Mar 2017 04:47
URI: http://sro.sussex.ac.uk/id/eprint/52588

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