Genetic association suggests that SMOC1 mediates between prenatal sex hormones and digit ratio

Lawrance-Owen, Adam J, Bargary, Gary, Bosten, Jenny M, Goodbourn, Patrick T, Hogg, Ruth E and Mollon, J D (2013) Genetic association suggests that SMOC1 mediates between prenatal sex hormones and digit ratio. Human Genetics, 132 (4). pp. 415-421. ISSN 0340-6717

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Abstract

Men and women differ statistically in the relative lengths of their index and ring fingers; and the ratio of these lengths has been used as a biomarker for prenatal testosterone. The ratio has been correlated with a wide range of traits and conditions including prostate cancer, obesity, autism, ADHD, and sexual orientation. In a genome-wide association study of 979 healthy adults, we find that digit ratio is strongly associated with variation upstream of SMOC1 (rs4902759: P = 1.41 × 10(-8)) and a meta-analysis of this and an independent study shows a probability of P = 1.5 × 10(-11). The protein encoded by SMOC1 has recently been shown to play a critical role in limb development; its expression in prostate tissue is dependent on sex hormones, and it has been implicated in the sexually dimorphic development of the gonads. We put forward the hypothesis that SMOC1 provides a link between prenatal hormone exposure and digit ratio.

Item Type: Article
Schools and Departments: School of Psychology > Psychology
Subjects: Q Science > QM Human anatomy > QM0001 General
Depositing User: Jenny Bosten
Date Deposited: 27 Jan 2015 19:03
Last Modified: 08 Mar 2017 08:04
URI: http://sro.sussex.ac.uk/id/eprint/52522

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