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TRP channels in airway smooth muscle as therapeutic targets

journal contribution
posted on 2023-06-08, 19:47 authored by Martin Gosling, Chris Poll, Su Li
Cation channels are of fundamental importance in regulating the function of airway smooth cells especially bronchoconstriction in response to spasmogens, and are therefore key players in the pathogenesis of asthma. To date, the identity of these cation channels remains a mystery. However, the recently emerged transient receptor potential (TRP) cation channel family has provided several promising channel candidates. The identification of the key TRP channels involved in regulating airway smooth muscle contractility, and therefore airway tone, could provide new and exciting prospects for the development of novel therapies for the treatment of airway diseases such as asthma. © Springer-Verlag 2005.

History

Publication status

  • Published

Journal

Naunyn-Schmiedeberg's Archives of Pharmacology

ISSN

0028-1298

Publisher

Springer-Verlag

Issue

4

Volume

371

Page range

277-284

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2015-01-26

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