Molecular and cellular changes in vein grafts: influence of pulsatile stretch

Powell, Janet T and Gosling, Martin (1998) Molecular and cellular changes in vein grafts: influence of pulsatile stretch. Current Opinion in Cardiology, 13 (6). pp. 453-458. ISSN 0268-4705

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Abstract

Adaptation of saphenous vein, with its intrinsic myogenic tone, from the low-pressure, minimally pulsatile flow of the venous system to the pulsatile flow of the arterial circulation is a minor miracle. Changes in gene expression caused by the pulsatile circumferential deformation (cyclic strain) initiate changes in gene expression, which lead to both vein graft adaptation and pathology. Removal of circumferential deformation by external stenting attenuates the early changes in gene expression and the later development of intimal hyperplasia. Pathways for the transduction of cyclic strain into cellular events have been elucidated in cultured vascular cells: The important second messengers include calcium and reactive oxygen species.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry
Depositing User: Tom Gittoes
Date Deposited: 27 Jan 2015 12:02
Last Modified: 27 Jan 2015 12:02
URI: http://sro.sussex.ac.uk/id/eprint/52447
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