Age-related effects on the neural correlates of autobiographical memory retrieval

St Jacques, Peggy L, Rubin, David C and Cabeza, Roberto (2012) Age-related effects on the neural correlates of autobiographical memory retrieval. Neurobiology of Aging, 33 (7). pp. 1298-1310. ISSN 1558-1497

[img] PDF
Restricted to SRO admin only

Download (716kB)

Abstract

Older adults recall less episodically rich autobiographical memories (AM), however, the neural basis of this effect is not clear. Using functional MRI, we examined the effects of age during search and elaboration phases of AM retrieval. Our results suggest that the age-related attenuation in the episodic richness of AMs is associated with difficulty in the strategic retrieval processes underlying recovery of information during elaboration. First, age effects on AM activity were more pronounced during elaboration than search, with older adults showing less sustained recruitment of the hippocampus and ventrolateral prefrontal cortex (VLPFC) for less episodically rich AMs. Second, there was an age-related reduction in the modulation of top-down coupling of the VLPFC on the hippocampus for episodically rich AMs. In sum, the present study shows that changes in the sustained response and coupling of the hippocampus and prefrontal cortex (PFC) underlie age-related reductions in episodic richness of the personal past.

Item Type: Article
Schools and Departments: School of Psychology > Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
B Philosophy. Psychology. Religion > BF Psychology > BF0180 Experimental psychology
B Philosophy. Psychology. Religion > BF Psychology > BF0309 Consciousness. Cognition Including learning, attention, comprehension, memory, imagination, genius, intelligence, thought and thinking, psycholinguistics, mental fatigue
Depositing User: Peggy St Jacques
Date Deposited: 21 Jan 2015 09:20
Last Modified: 08 Mar 2017 08:15
URI: http://sro.sussex.ac.uk/id/eprint/52299

View download statistics for this item

📧 Request an update