Optimizing pyramided transgenic Bt crops for sustainable pest management

Carrière, Yves, Crickmore, Neil and Tabashnik, Bruce E (2015) Optimizing pyramided transgenic Bt crops for sustainable pest management. Nature Biotechnology, 33 (2). pp. 161-168. ISSN 1087-0156

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Abstract

Transgenic crop pyramids producing two or more Bacillus thuringiensis (Bt) toxins that kill the same insect pest have been widely used to delay evolution of pest resistance. To assess the potential of pyramids to achieve this goal, we analyze data from 38 studies that report effects of ten Bt toxins used in transgenic crops against 15 insect pests. We find that compared with optimal low levels of insect survival, survival on currently used pyramids is often higher for both susceptible insects and insects resistant to one of the toxins in the pyramid. Furthermore, we find that cross-resistance and antagonism between toxins used in pyramids are common, and that these problems are associated with the similarity of the amino acid sequences of domains II and III of the toxins, respectively. This analysis should assist in future pyramid design and the development of sustainable resistance management strategies.

Item Type: Article
Additional Information: Online first edition
Schools and Departments: School of Life Sciences > Biochemistry
Subjects: Q Science > QD Chemistry > QD0241 Organic chemistry > QD0415 Biochemistry
Depositing User: Catrina Hey
Date Deposited: 19 Jan 2015 17:09
Last Modified: 12 Apr 2016 12:02
URI: http://sro.sussex.ac.uk/id/eprint/52253
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