The squalestatins: potent inhibitors of squalene synthase, 3-hydroxymethyl derivatives

Cox, Brian, Hutson, Julie L, Keeling, Suzanne E, Kirk, Barrie E, Srikantha, Anton R P and Watson, Nigel S (1994) The squalestatins: potent inhibitors of squalene synthase, 3-hydroxymethyl derivatives. Bioorganic and Medicinal Chemistry Letters, 4 (16). pp. 1931-1936. ISSN 0960-894X

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Abstract

A series of 3-hydroxymethyl derivatives of squalestatin 1 was prepared as inhibitors of squalene synthase. Potent in vitro inhibitory activity is retained in those analogues which possess C-6 and C-1 substituents analogous to those found in 1.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry
Depositing User: Tom Gittoes
Date Deposited: 14 Jan 2015 09:21
Last Modified: 14 Jan 2015 09:21
URI: http://sro.sussex.ac.uk/id/eprint/52119
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