A versatile procedure for the generation of nucleoside 5'-carboxylic acids using nucleoside oxidase

Mahmoudian, Mahmoud, Rudd, Brian A M, Cox, Brian, Drake, Chris S, Hall, Richard M, Stead, Paul, Dawson, Michael J, Chandler, Malcolm, Livermore, David G, Turner, Nicholas J and Jenkins, Gareth (1998) A versatile procedure for the generation of nucleoside 5'-carboxylic acids using nucleoside oxidase. Tetrahedron, 54 (28). pp. 8171-8182. ISSN 0040-4020

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Abstract

The nucleoside oxidase from Stenotrophomonas maltophilia (FERM BP-2252) has been used to generate 5′-carboxylic acid derivatives of nucleoside analogues. The enzyme, which has a surprisingly broad substrate specificity for unnatural nucleosides, has been immobilised and used at preparative scale.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry
Depositing User: Tom Gittoes
Date Deposited: 13 Jan 2015 13:54
Last Modified: 13 Jan 2015 13:54
URI: http://sro.sussex.ac.uk/id/eprint/52087
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