Evaluation of N-(phenylmethyl)-4-[5-(phenylmethyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-4-yl]benzamide inhibitors of Mycobacterium tuberculosis growth

Wall, Michael D, Oshin, Michael, Chung, Gavin A C, Parkhouse, Tony, Gore, Andrea, Herreros, Esperanza, Cox, Brian, Duncan, Ken, Evans, Brian, Everett, Martin and Mendoza, Alfonso (2007) Evaluation of N-(phenylmethyl)-4-[5-(phenylmethyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-4-yl]benzamide inhibitors of Mycobacterium tuberculosis growth. Bioorganic and Medicinal Chemistry Letters, 17 (10). pp. 2740-2744. ISSN 0960-894X

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Abstract

The biological evaluation of imidazopiperidines as FAS II inhibitors of Mycobacterium tuberculosis growth has been carried out with a view to assessment of potential as lead compounds for the development of a new TB drug. A summary of the hit evaluation and current challenges is described herein.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry
Depositing User: Tom Gittoes
Date Deposited: 13 Jan 2015 10:23
Last Modified: 13 Jan 2015 10:23
URI: http://sro.sussex.ac.uk/id/eprint/52057
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