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2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists
journal contribution
posted on 2023-06-08, 19:29 authored by David A Sandham, Clive Aldcroft, Urs Baettig, Lucy Barker, David Beer, Gurdip Bhalay, Zarin Brown, Gerald Dubois, David Budd, Louise Bidlake, Emma Campbell, Brian Cox, Brian Everatt, David Harrison, Catherine J Leblanc, Jodie Manini, Rachael Profit, Rowan Stringer, Katy S Thompson, Katharine L Turner, Morris F Tweed, Christopher Walker, Simon J Watson, Steven Whitebread, Jennifer Willis, Gareth Williams, Caroline WilsonHigh throughput screening identified a phenoxyacetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a compound with functional potency for inhibition of human eosinophil shape change and oral bioavailability in the rat.
History
Publication status
- Published
Journal
Bioorganic and Medicinal Chemistry LettersISSN
0960-894XPublisher
ElsevierExternal DOI
Issue
15Volume
17Page range
4347-4350Department affiliated with
- Chemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-01-13Usage metrics
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