2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists

Sandham, David A, Aldcroft, Clive, Baettig, Urs, Barker, Lucy, Beer, David, Bhalay, Gurdip, Brown, Zarin, Dubois, Gerald, Budd, David, Bidlake, Louise, Campbell, Emma, Cox, Brian, Everatt, Brian, Harrison, David, Leblanc, Catherine J, Manini, Jodie, Profit, Rachael, Stringer, Rowan, Thompson, Katy S, Turner, Katharine L, Tweed, Morris F, Walker, Christopher, Watson, Simon J, Whitebread, Steven, Willis, Jennifer, Williams, Gareth and Wilson, Caroline (2007) 2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists. Bioorganic and Medicinal Chemistry Letters, 17 (15). pp. 4347-4350. ISSN 0960-894X

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Abstract

High throughput screening identified a phenoxyacetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a compound with functional potency for inhibition of human eosinophil shape change and oral bioavailability in the rat.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry
Depositing User: Tom Gittoes
Date Deposited: 13 Jan 2015 07:44
Last Modified: 13 Jan 2015 07:44
URI: http://sro.sussex.ac.uk/id/eprint/52055
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