Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 1: Quaternary amines

Hunt, Thomas, Atherton-Watson, Hazel C, Axford, Jake, Collingwood, Stephen P, Coote, Kevin J, Cox, Brian, Czarnecki, Sarah, Danahay, Henry, Devereux, Nick, Howsham, Catherine, Hunt, Peter, Paddock, Victoria, Paisley, Derek and Young, Alice (2012) Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 1: Quaternary amines. Bioorganic and Medicinal Chemistry Letters, 22 (2). pp. 929-932. ISSN 0960-894X

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Abstract

We report the identification of a novel series of human epithelial sodium channel (ENaC) blockers that are structurally distinct from the pyrazinoyl guanidine chemotype found in prototypical ENaC blockers such as amiloride. Following a rational design hypothesis a series of quaternary amines were prepared and evaluated for their ability to block ion transport via ENaC in human bronchial epithelial cells (HBECs). Compound 11 has an IC50 of 200 nM and is efficacious in the Guinea-pig tracheal potential difference (TPD) model of ENaC blockade with an ED50 of 44 μg kg−1 at 1 h. As such, pyrazinoyl quaternary amines represent the first examples of a promising new class of human ENaC blockers.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry
Depositing User: Tom Gittoes
Date Deposited: 12 Jan 2015 14:23
Last Modified: 12 Jan 2015 14:23
URI: http://sro.sussex.ac.uk/id/eprint/52044
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