Identification of novel IP receptor agonists using historical ligand biased chemical arrays

McKeown, Stephen C, Charlton, Steven J, Cox, Brian, Fitch, Helen, Howson, Christopher D, Leblanc, Catherine, Meyer, Arndt, Rosethorne, Elizabeth M and Stanley, Emily (2014) Identification of novel IP receptor agonists using historical ligand biased chemical arrays. Bioorganic & Medicinal Chemistry Letters, 24 (10). pp. 2247-2250. ISSN 0960-894X

Full text not available from this repository.

Abstract

By considering published structural information we have designed high throughput biaryl lipophilic acid arrays leveraging facile chemistry to expedite their synthesis. We rapidly identified multiple hits which were of suitable IP agonist potency. These relatively simple and strategically undecorated molecules present an ideal opportunity for optimization towards our target candidate profile.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry
Depositing User: Tom Gittoes
Date Deposited: 12 Jan 2015 11:29
Last Modified: 12 Jan 2015 11:29
URI: http://sro.sussex.ac.uk/id/eprint/52036
📧 Request an update