HTS approaches to voltage-gated ion channel drug discovery

Denyer, Jane, Worley, Jennings, Cox, Brian, Allenby, Gary and Banks, Martyn (1998) HTS approaches to voltage-gated ion channel drug discovery. Drug Discovery Today, 3 (7). pp. 323-332. ISSN 1359-6446

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Abstract

Voltage-gated ion channels are emerging as a target class of increasing importance to the pharmaceutical industry because of their relevance to a wide variety of diseases in the cardiovascular, CNS and metabolic areas. In the quest to identify novel lead molecules against these targets, drug discovery programmes are increasingly making use of HTS approaches. The authors describe the current technologies available for voltage-gated ion-channel screening, their application to HTS campaigns and the current limitations and emerging technologies within this area.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry
Depositing User: Tom Gittoes
Date Deposited: 12 Jan 2015 11:04
Last Modified: 12 Jan 2015 11:04
URI: http://sro.sussex.ac.uk/id/eprint/52034
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