Natural products as leads for new pharmaceuticals

Buss, A D, Cox, B and Waigh, R D (2003) Natural products as leads for new pharmaceuticals. In: Abraham, Donald J (ed.) Burger's medicinal chemistry and drug discovery. Wiley-Blackwell. ISBN 9780471266945

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Abstract

A review of the use of natural products as starting points in the search for new pharmaceuticals, covering the broad areas of “Drugs affecting the centeral nervous system, ” “Neuromuscular blocking drugs,” “Anticancer drugs,” “Marine sources,” “Antibiotics,” “Cardiovascular drugs,” “Antiasthma drugs,” and “Antiparasitic drugs.” The review covers more than 100 years of development, from “old” drugs, such as morphine and quinine, to very recent discoveries, such as conotoxin and galantamine, and includes a discussion of the attributes of natural products as leads in the drug discovery process. Between 1990 and 2000, a total of 41 drugs derived from natural products were launched on the market by major pharmaceutical companies. In the chosen examples, the process of drug development is traced from the discovery of the activity of the natural compound, through chemical modification and biological evaluation, to either success or failure as a clinical product, highlighting the very different pathways to innovation that occur in each product.

Item Type: Book Section
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry
Depositing User: Tom Gittoes
Date Deposited: 12 Jan 2015 11:04
Last Modified: 12 Jan 2015 11:04
URI: http://sro.sussex.ac.uk/id/eprint/52016
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