Solubility of chlordiazepoxide,diazepam,and lorazepam in ethanol+water mixtures at 303.2 K

Jouyban, Abolghasem, Shokri, Javad, Jalali, Mohammad, Hassanzadeh, Davoud, Acree Jr., William E, Ghafourian, Taravat and Nokhodchi, Ali (2009) Solubility of chlordiazepoxide,diazepam,and lorazepam in ethanol+water mixtures at 303.2 K. Journal of Chemical and Engineering Data, 54 (7). pp. 2142-2145. ISSN 0021-9568

Full text not available from this repository.

Abstract

Experimental solubilities of three benzodiazepines (chlordiazepoxide, diazepam,and lorazepam) in ethanol+water mixtures at 303.2 K are reported.The solubility of drugs was increased with the addition of ethanol and reached the maximum value of a volume fraction of 90 % of ethanol.The Jouyban-Acree model was used to fit the experimental data,and the solubilities were reproduced using previously trained version of the Jouyban-Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the models were 8.6 %,21.9 % and 19.3 %,respectively,for the fitted model,the trained version for ethanol+water mixtures and generally trained version for various organic solvents+water mixtures. © 2009 American Chemical Society.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry
Depositing User: Tom Gittoes
Date Deposited: 21 Dec 2014 19:47
Last Modified: 21 Dec 2014 19:47
URI: http://sro.sussex.ac.uk/id/eprint/51821
📧 Request an update