Role of nanocarrier systems in cancer nanotherapy

Mozafari, M R, Pardakhty, A, Azarmi, S, Jazayeri, J A, Nokhodchi, A and Omri, A (2009) Role of nanocarrier systems in cancer nanotherapy. Journal of Liposome Research, 19 (4). pp. 310-321. ISSN 0898-2104

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Abstract

Cancer continues to be a major cause of morbidity and mortality worldwide. While discovery of new drugs and cancer chemotherapy opened a new era for the treatment of tumors, optimized concentration of drug at the target site is only possible at the expense of severe side effects. Nanoscale carrier systems have the potential to limit drug toxicity and achieve tumor localization. When linked with tumor-targeting moieties, such as tumor-specific ligands or monoclonal antibodies, the nanocarriers can be used to target cancer-specific receptors, tumor antigens, and tumor vasculatures with high affinity and precision. This article is an overview of advances and prospects in the applications of nanocarrier technology in cancer therapy. Applications of nanoliposomes, dendrimers, and nanoparticles in cancer therapy are explained, along with their preparation methods and targeting strategies.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry
Depositing User: Tom Gittoes
Date Deposited: 21 Dec 2014 19:44
Last Modified: 21 Dec 2014 19:44
URI: http://sro.sussex.ac.uk/id/eprint/51819
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