Solubility of benzodiazepines in polyethylene glycol 200 + water mixtures at 303.2 K

Jouyban, Abolghasem, Shokri, Javad, Barzegar-Jalali, Mohammad, Hassanzadeh, Davoud, Acree Jr, William E, Ghafourian, Taravat and Nokhodchi, Ali (2010) Solubility of benzodiazepines in polyethylene glycol 200 + water mixtures at 303.2 K. Journal of Chemical and Engineering Data, 55 (1). pp. 519-522. ISSN 0021-9568

Full text not available from this repository.

Abstract

Experimental solubilities of chlordiazepoxide, diazepam, and lorazepam in polyethylene glycol 200 (PEG 200) + water mixtures at 303.2 K were reported. The solubility of each drug increased exponentially with the addition of PEG 200 and reached the maximum value in neat PEG 200. The Jouyban-Acree model was used to mathematically describe the experimental data, and the solubilities were predicted using a previously trained version of the Jouyban-Acree model for PEG + water mixtures and the solubility data in monosolvents. The overall mean relative deviations of the models were 3.7% and 18.3%, respectively, for the fitted model and the trained version. © 2010 American Chemical Society.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry
Depositing User: Tom Gittoes
Date Deposited: 18 Dec 2014 14:56
Last Modified: 18 Dec 2014 14:56
URI: http://sro.sussex.ac.uk/id/eprint/51809
📧 Request an update