Solubility prediction of clonazepam in aqueous mixtures of ethanol, polyethylene glycol 200 and propylene glycol at 30°C

Jouyban, A, Shokri, J, Barzegar-Jalali, M, Hassanzadeh, D, Acree, Jr, W E, Ghafourian, T and Nokhodchi, A (2010) Solubility prediction of clonazepam in aqueous mixtures of ethanol, polyethylene glycol 200 and propylene glycol at 30°C. Journal of Drug Delivery Science and Technology, 20 (2). pp. 149-151. ISSN 1773-2247

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Abstract

Solubility of clonazepam in aqueous binary mixtures of ethanol, polyethylene glycol 200 and propylene glycol was determined at 30°C using the shake flask method. The maximum solubility of clonazepam was observed at volume fraction of 0.90 ofethanol, whereas for aqueous mixtures of polyethylene glycol 200 and propylene glycol, the maximum values were observed in the neat cosolvents. The generated data was fitted to the Jouyban-Acree model and its constants were computed, then the back-calculated solubilities were compared with the corresponding experimental values by calculating the mean percentage deviation (MPD) in which the overall MPD for three cosolvent systems was 7.0 %. The solubility data in cosolvent + water mixtures was predicted using previously trained versions of the Jouyban-Acree model and the prediction MPDs were 13.4, 542 and 24.9 %, respectively for ethanol, polyethylene glycol 200 and propylene glycol mixtures and the overall MPD was 30.8 %.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry
Depositing User: Tom Gittoes
Date Deposited: 18 Dec 2014 15:59
Last Modified: 18 Dec 2014 15:59
URI: http://sro.sussex.ac.uk/id/eprint/51806
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