Enhancement of percutaneous absorption of Finasteride by cosolvents, cosurfactant and surfactants

Javadzadeh, Yousef, Shokri, Javad, Hallaj-Nezhadi, Somayeh, Hamishehkar, Hamed and Nokhodchi, Ali (2010) Enhancement of percutaneous absorption of Finasteride by cosolvents, cosurfactant and surfactants. Pharmaceutical Development and Technology, 15 (6). pp. 619-625. ISSN 1083-7450

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Abstract

The enhancing effects of routinely used co-solvents, propylene glycol and 2-propanol, anionic and cationic surfactants and a co-surfactant with different concentrations were evaluated on the skin permeation of Finasteride. In vitro permeation experiments with rat skin revealed that the solvent mixture is a very important factor in the penetration of Finasteride through the skin. Unexpectedly, cationic and anionic surfactants in various concentrations did not show any enhancement effect on drug transdermal absorption but co-surfactant Transcutol P increased skin penetration of Finastride significantly. Transcutol P with 0.25% and 1% showed the best enhancement in the initial and final sampling time, respectively. Transcutol P in a concentration of 0.25% increased skin absorption of the drug nearly 3.6 times in the first 15min. The highest enhancement ratio (ER) was gained in the presence of 1% Transcutol P (ER = 5.98). In this study, among the different topical Finastride formulations, Transcutol P 1% in combination with water, propylene glycol and 2-propanol (30, 10, and 60) showed the highest enhancement ratio. © 2010 Informa Healthcare USA, Inc.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry
Depositing User: Tom Gittoes
Date Deposited: 21 Dec 2014 19:19
Last Modified: 21 Dec 2014 19:19
URI: http://sro.sussex.ac.uk/id/eprint/51788
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