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Homeostatic regulation of meiotic DSB formation by ATM/ATR
journal contribution
posted on 2023-06-08, 19:15 authored by Timothy Cooper, Kayleigh Wardell, Valerie Garcia, Matt NealeMatt NealeAtaxia-telangiectasia mutated (ATM) and RAD3-related (ATR) are widely known as being central players in the mitotic DNA damage response (DDR), mounting responses to DNA double-strand breaks (DSBs) and single-stranded DNA (ssDNA) respectively. The DDR signalling cascade couples cell cycle control to damage-sensing and repair processes in order to prevent untimely cell cycle progression while damage still persists [1]. Both ATM/ATR are, however, also emerging as essential factors in the process of meiosis; a specialised cell cycle programme responsible for the formation of haploid gametes via two sequential nuclear divisions. Central to achieving accurate meiotic chromosome segregation is the introduction of numerous DSBs spread across the genome by the evolutionarily conserved enzyme, Spo11. This review seeks to explore and address how cells utilise ATM/ATR pathways to regulate Spo11-DSB formation, establish DSB homeostasis and ensure meiosis is completed unperturbed.
Funding
Biochemical reconstitution of DNA repair reactions on intact chromatin; G0986; EUROPEAN UNION; 311336
History
Publication status
- Published
File Version
- Published version
Journal
Experimental Cell ResearchISSN
1090-2422Publisher
ElsevierExternal DOI
Issue
1Volume
329Page range
124-131Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2014-12-09First Compliant Deposit (FCD) Date
2014-12-09Usage metrics
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