Homeostatic regulation of meiotic DSB formation by ATM/ATR

Cooper, Tim J, Wardell, Kayleigh, Garcia, Valerie and Neale, Matthew J (2014) Homeostatic regulation of meiotic DSB formation by ATM/ATR. Experimental Cell Research, 329 (1). pp. 124-131. ISSN 1090-2422

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Abstract

Ataxia-telangiectasia mutated (ATM) and RAD3-related (ATR) are widely known as being central players in the mitotic DNA damage response (DDR), mounting responses to DNA double-strand breaks (DSBs) and single-stranded DNA (ssDNA) respectively. The DDR signalling cascade couples cell cycle control to damage-sensing and repair processes in order to prevent untimely cell cycle progression while damage still persists [1]. Both ATM/ATR are, however, also emerging as essential factors in the process of meiosis; a specialised cell cycle programme responsible for the formation of haploid gametes via two sequential nuclear divisions. Central to achieving accurate meiotic chromosome segregation is the introduction of numerous DSBs spread across the genome by the evolutionarily conserved enzyme, Spo11. This review seeks to explore and address how cells utilise ATM/ATR pathways to regulate Spo11-DSB formation, establish DSB homeostasis and ensure meiosis is completed unperturbed.

Item Type: Article
Keywords: ATM; ATR; Mec1; Meiosis; Recombination; Spo11; Tel1; DSB
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Subjects: Q Science > Q Science (General)
Depositing User: Tim Cooper
Date Deposited: 09 Dec 2014 13:31
Last Modified: 06 Mar 2017 14:01
URI: http://sro.sussex.ac.uk/id/eprint/51651

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Biochemical reconstitution of DNA repair reactions on intact chromatinG0986EUROPEAN UNION311336