Sex differences in disease genetics: evidence, evolution, and detection

Gilks, William P, Abbott, Jessica K and Morrow, Edward H (2014) Sex differences in disease genetics: evidence, evolution, and detection. Trends in Genetics, 30 (10). pp. 453-463. ISSN 0168-9525

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Abstract

Understanding the genetic architecture of disease is an enormous challenge, and should be guided by evolutionary principles. Recent studies in evolutionary genetics show that sexual selection can have a profound influence on the genetic architecture of complex traits. Here, we summarise data from heritability studies and genome-wide association studies (GWASs) showing that common genetic variation influences many diseases and medically relevant traits in a sex-dependent manner. In addition, we discuss how the discovery of sex-dependent effects in population samples is improved by joint interaction analysis (rather than separate-sex), as well as by recently developed software. Finally, we argue that although genetic variation that has sex-dependent effects on disease risk could be maintained by mutation-selection balance and genetic drift, recent evidence indicates that intra-locus sexual conflict could be a powerful influence on complex trait architecture, and maintain sex-dependent disease risk alleles in a population because they are beneficial to the opposite sex.

Item Type: Article
Schools and Departments: School of Life Sciences > Evolution, Behaviour and Environment
Subjects: H Social Sciences > HQ The Family. Marriage. Women > HQ1075 Sex role
Q Science
Q Science > QH Natural history > QH0301 Biology > QH0426 Genetics > QH0447 Genes. Alleles. Genome
Q Science > QH Natural history > QH0301 Biology > QH0426 Genetics > QH0460 Mutations
R Medicine > R Medicine (General)
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Depositing User: William Gilks
Date Deposited: 04 Nov 2014 13:54
Last Modified: 07 Mar 2017 04:46
URI: http://sro.sussex.ac.uk/id/eprint/50853

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Project NameSussex Project NumberFunderFunder Ref
2Sexes_1Genome: Sex-specific genetic effects on fitness and human diseaseG0781EUROPEAN UNION2011-STG280632