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Association of heat shock protein70-2 (HSP70-2) gene polymorphism with coronary artery disease in an Iranian population

journal contribution
posted on 2023-06-08, 18:51 authored by Maryam Mardan-Nik, Alireza Pasdar, Khadijeh Jamialahmadi, Atefeh Biabangard-Zak, Seyed Reza Mirhafez, Marzieh Ghalandari, Mohammad Tajfard, Mohsen Mohebati, Habobollah Esmaily, Gordon FernsGordon Ferns, Majid Ghayour-Mobarhan
Background: Coronary artery disease (CAD) is an inflammatory process and a major cause of mortality and morbidity. The (heat shock protein70-2) HSP70-2 gene is reported to be associated with coronary artery disease possibly by affecting the regulation of pro-inflammatory cytokines such as TNF-alpha. The association between CAD and the HSP70-2 gene +1267A>G polymorphism has been studied in some populations but there are no data about this association in the Iranian population. Aim: We have investigated the association between the HSP70-2 gene +1267A>G polymorphism and angiographically defined CAD within an Iranian population. Methods: We determined the presence of the HSP70-2 gene +1267A>G polymorphism in 628 patients with CAD and 307 healthy individuals using PCR-RFLP. Of the patients, 433 (68%) had >50% stenosis (CAD+) and the remaining 195 patients had <50% stenosis (CAD), based on coronary angiography. Angiogram positive patients were subdivided into three groups: those with single (n = 113), double (n = 134), and triple vessels (n = 186) disease. Results: A significant higher frequency of AG + GG genotypes (G allele carriers) was observed in angiogram positive and angiogram negative groups compared to controls in a dominant analysis model of the HSP70-2 gene +1267A>G position (51.2 vs. 43.2, P = 0.002, OR = 137) (51.0 vs. 43.2, P = 0.01, OR = 1.37). The allele frequency of the HSP70-2 G was also significantly higher in angiogram positive and angiogram negative groups compared to the control group (512 vs. 43.2, P = 0.002, OR = 1.37) (51.0 vs. 432, P = 0.01, OR = 1.37). Conclusion: These results suggest that HSP70-2 +1267 polymorphism may influence the risk of CAD in Iranian population, however further studies are needed to clarify the role of other HSP70-2 gene polymorphisms in the pathogenesis of the CAD.

History

Publication status

  • Published

Journal

Gene

ISSN

0378-1119

Publisher

Elsevier

Issue

2

Volume

550

Page range

180-184

Department affiliated with

  • Division of Medical Education Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2014-11-03

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