Association of heat shock protein70-2 (HSP70-2) gene polymorphism with coronary artery disease in an Iranian population

Mardan-Nik, Maryam, Pasdar, Alireza, Jamialahmadi, Khadijeh, Biabangard-Zak, Atefeh, Mirhafez, Seyed Reza, Ghalandari, Marzieh, Tajfard, Mohammad, Mohebati, Mohsen, Esmaily, Habobollah, Ferns, Gordon A and Ghayour-Mobarhan, Majid (2014) Association of heat shock protein70-2 (HSP70-2) gene polymorphism with coronary artery disease in an Iranian population. Gene, 550 (2). pp. 180-184. ISSN 0378-1119

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Abstract

Background: Coronary artery disease (CAD) is an inflammatory process and a major cause of mortality and morbidity. The (heat shock protein70-2) HSP70-2 gene is reported to be associated with coronary artery disease possibly by affecting the regulation of pro-inflammatory cytokines such as TNF-alpha. The association between CAD and the HSP70-2 gene +1267A>G polymorphism has been studied in some populations but there are no data about this association in the Iranian population.

Aim: We have investigated the association between the HSP70-2 gene +1267A>G polymorphism and angiographically defined CAD within an Iranian population.

Methods: We determined the presence of the HSP70-2 gene +1267A>G polymorphism in 628 patients with CAD and 307 healthy individuals using PCR-RFLP. Of the patients, 433 (68%) had >50% stenosis (CAD+) and the remaining 195 patients had <50% stenosis (CAD), based on coronary angiography. Angiogram positive patients were subdivided into three groups: those with single (n = 113), double (n = 134), and triple vessels (n = 186) disease.

Results: A significant higher frequency of AG + GG genotypes (G allele carriers) was observed in angiogram positive and angiogram negative groups compared to controls in a dominant analysis model of the HSP70-2 gene +1267A>G position (51.2 vs. 43.2, P = 0.002, OR = 137) (51.0 vs. 43.2, P = 0.01, OR = 1.37). The allele frequency of the HSP70-2 G was also significantly higher in angiogram positive and angiogram negative groups compared to the control group (512 vs. 43.2, P = 0.002, OR = 1.37) (51.0 vs. 432, P = 0.01, OR = 1.37).

Conclusion: These results suggest that HSP70-2 +1267 polymorphism may influence the risk of CAD in Iranian population, however further studies are needed to clarify the role of other HSP70-2 gene polymorphisms in the pathogenesis of the CAD.

Item Type: Article
Keywords: Coronary artery disease; Heat shock protein70-2; HSP70-2 gene+1267A > G polymorphism; PCR-RFLP
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Subjects: R Medicine > RB Pathology > RB037 Clinical pathology. Laboratory technique
Depositing User: Gordon Ferns
Date Deposited: 03 Nov 2014 07:43
Last Modified: 03 Nov 2014 07:43
URI: http://sro.sussex.ac.uk/id/eprint/50836
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