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Grey-matter texture abnormalities and reduced hippocampal volume are distinguishing features of schizophrenia
journal contribution
posted on 2023-06-08, 18:49 authored by Eugenia Radulescu, Balaji Ganeshan, Sukhwinder S Shergill, Nick Medford, Chris ChatwinChris Chatwin, Rupert YoungRupert Young, Hugo CritchleyHugo CritchleyNeurodevelopmental processes are widely believed to underlie schizophrenia. Analysis of brain texture from conventional magnetic resonance imaging (MRI) can detect disturbance in brain cytoarchitecture. We tested the hypothesis that patients with schizophrenia manifest quantitative differences in brain texture that, alongside discrete volumetric changes, may serve as an endophenotypic biomarker. Texture analysis (TA) of grey matter distribution and voxel-based morphometry (VBM) of regional brain volumes were applied to MRI scans of 27 patients with schizophrenia and 24 controls. Texture parameters (uniformity and entropy) were also used as covariates in VBM analyses to test for correspondence with regional brain volume. Linear discriminant analysis tested if texture and volumetric data predicted diagnostic group membership (schizophrenia or control). We found that uniformity and entropy of grey matter differed significantly between individuals with schizophrenia and controls at the fine spatial scale (filter width below 2 mm). Within the schizophrenia group, these texture parameters correlated with volumes of the left hippocampus, right amygdala and cerebellum. The best predictor of diagnostic group membership was the combination of fine texture heterogeneity and left hippocampal size. This study highlights the presence of distributed grey-matter abnormalities in schizophrenia, and their relation to focal structural abnormality of the hippocampus. The conjunction of these features has potential as a neuroimaging endophenotype of schizophrenia.
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Publication status
- Published
File Version
- Accepted version
Journal
Psychiatry Research: NeuroimagingISSN
0925-4927Publisher
ElsevierIssue
3Volume
223Page range
179-186Department affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2015-06-19First Open Access (FOA) Date
2015-10-23First Compliant Deposit (FCD) Date
2014-10-28Usage metrics
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