Interaction of dipyridamole with phospholipid monolayers at the air-water interface: surface pressure and grazing incidence X-ray diffraction studies

Haas, H, Caetano, W, Borissevitch, G P, Tabak, M, Mosquera Sanchez, M I, Oliveira, O N, Scalas, E and Goldman, M (2001) Interaction of dipyridamole with phospholipid monolayers at the air-water interface: surface pressure and grazing incidence X-ray diffraction studies. Chemical Physics Letters, 335 (5-6). pp. 510-516. ISSN 0009-2614

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Abstract

Incorporation of dipyridamole (DIP) in Langmuir monolayers of the zwitterionic phospholipid dipalmitoylphosphatidylcholine (DPPC) has been investigated using surface pressure isotherm and grazing incidence X-ray diffraction (GIXD) measurements. An expansion in the pressure–area isotherms of the DPPC monolayer was observed, which was maximum in the liquid-expanded (LE) to liquid-condensed (LC) transition region and at a DIP concentration of 2 mol%. Accordingly, the GIXD measurements indicated an expansion of the 2D lattice in the LC phase up to a surface pressure of ca. 30 mN/m. A condensation effect on the DPPC packing for high DIP concentrations, as previously suggested, can be ruled out.

Item Type: Article
Schools and Departments: School of Mathematical and Physical Sciences > Mathematics
Subjects: Q Science > QD Chemistry > QD0450 Physical and theoretical chemistry
Depositing User: Enrico Scalas
Date Deposited: 01 Oct 2014 13:36
Last Modified: 01 Oct 2014 13:36
URI: http://sro.sussex.ac.uk/id/eprint/50296
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