Delta insulin-like growth factor binding protein-1 (Delta IGFBP-1): a marker of hepatic insulin resistance?

Borai, Anwar, Livingstone, Callum, Heald, Adrian H, Oyindamola, Yusuf and Ferns, Gordon (2014) Delta insulin-like growth factor binding protein-1 (Delta IGFBP-1): a marker of hepatic insulin resistance? Annals of Clinical Biochemistry, 51 (2). pp. 269-276. ISSN 0004-5632

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Abstract

Background Insulin-like growth factor binding protein-1 (IGFBP-1) is a hepatically synthesised protein which can be used as a marker of insulin resistance. We hypothesised that the fall in serum IGFBP-1 at 2h following a glucose load (IGFBP-1(0-2h)) would be a more robust measure of hepatic insulin resistance than a fasting level alone.
Methods All subjects had a standard 75g oral GTT including IGFBP-1 and insulin measurement to enable calculation of IGFBP-1(0-2h), Insulin(0-2h), and insulin sensitivity indices. At a second visit, subjects had a frequently sampled intravenous glucose tolerance test (FSIVGTT) in order to determine the insulin sensitivity index, Si.
Results Twenty-two individuals had normal glucose tolerance (NGT) and 9 impaired fasting glucose (IFG). IGFBP-1(0-2h) correlated with Si in total subjects (r=0.49, p=0.005) and NGT subjects (r=0.50, p=0.02) but not in IFG subjects (r=0.43, p=0.24). Insulin(0-2h)/IGFBP-1(0-2h) correlated significantly with Si in total subjects (r=-0.68, p<0.001) and in NGT subjects (r=-0.57, p=0.005). Multivariate analysis was fitted using different models while keeping other explanatory variables constant. The fasting IGFBP-1 model was a better predictor of Si (=0.431, p<0.0001) than the Insulin(0-2h)/IGFBP1(0-2h) model (=-0.185, p=0.004).
Conclusions The dynamic indices IGFBP-1(0-2h) and Insulin(0-2h)/IGFBP-1(0-2h) appear suitable markers of (hepatic) insulin resistance with potential clinical utility.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Subjects: R Medicine > RB Pathology > RB037 Clinical pathology. Laboratory technique
R Medicine > RC Internal medicine > RC0071 Examination. Diagnosis Including radiography
Depositing User: Gordon Ferns
Date Deposited: 12 Sep 2014 09:34
Last Modified: 12 Sep 2014 09:34
URI: http://sro.sussex.ac.uk/id/eprint/49905
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