University of Sussex
Browse
journal.ppat.1004038.pdf (2.77 MB)

Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria

Download (2.77 MB)
journal contribution
posted on 2023-06-08, 17:55 authored by Delmiro Fernandez-Reyes, Peter Nilsson, Julie Bachmann, Florence Burte, Ianina Conte, Biobele J Brown, Adebola E Orimadegun, Wasiu A. Ajetunmobi, Nathaniel K Afolabi, Francis Akinkunmi, Samuel Omokhodion, Felix O Akinbami, Wuraola A Shokunbi, Caroline Kampf, Yudi Pawitan, Mathias Uhlén, Olugbemiro Sodeinde, Jochen M Schwenk, Mats Wahlgren
Systemic inflammation and sequestration of parasitized erythrocytes are central processes in the pathophysiology of severe Plasmodium falciparum childhood malaria. However, it is still not understood why some children are more at risks to develop malaria complications than others. To identify human proteins in plasma related to childhood malaria syndromes, multiplex antibody suspension bead arrays were employed. Out of the 1,015 proteins analyzed in plasma from more than 700 children, 41 differed between malaria infected children and community controls, whereas 13 discriminated uncomplicated malaria from severe malaria syndromes. Markers of oxidative stress were found related to severe malaria anemia while markers of endothelial activation, platelet adhesion and muscular damage were identified in relation to children with cerebral malaria. These findings suggest the presence of generalized vascular inflammation, vascular wall modulations, activation of endothelium and unbalanced glucose metabolism in severe malaria. The increased levels of specific muscle proteins in plasma implicate potential muscle damage and microvasculature lesions during the course of cerebral malaria.

Funding

U117585869; MRC

History

Publication status

  • Published

File Version

  • Published version

Journal

PLoS Pathogens

ISSN

1553-7366

Publisher

Public Library of Science

Issue

4

Volume

10

Article number

e1004038

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2014-07-24

First Open Access (FOA) Date

2014-07-24

First Compliant Deposit (FCD) Date

2014-07-24

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC