Detection of tuberculosis in HIV-infected and - uninfected African adults using whole blood RNA expression signatures: a case-control study

Cattamanchi, Adithya, Kaforou, Myrsini, Wright, Victoria J, Oni, Tolu, French, Neil, Anderson, Suzanne T, Bangani, Nonzwakazi, Banwell, Claire M, Brent, Andrew J, Crampin, Amelia C, Dockrell, Hazel M, Eley, Brian, Heyderman, Robert S, Hibberd, Martin L, Kern, Florian, Langford, Paul R, Ling, Ling, Mendelson, Marc, Ottenhoff, Tom H, Zgambo, Femia, Wilkinson, Robert J, Coin, Lachlan J and Levin, Michael (2013) Detection of tuberculosis in HIV-infected and - uninfected African adults using whole blood RNA expression signatures: a case-control study. PLoS Medicine, 10 (10). e1001538. ISSN 1549-1676

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Abstract

A major impediment to tuberculosis control in Africa is the difficulty in diagnosing active tuberculosis (TB), particularly in the context of HIV infection. We hypothesized that a unique host blood RNA transcriptional signature would distinguish TB from other diseases (OD) in HIV-infected and -uninfected patients, and that this could be the basis of a simple diagnostic test.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Subjects: R Medicine
Depositing User: Sandy Gray
Date Deposited: 02 Jul 2014 07:48
Last Modified: 07 Mar 2017 01:56
URI: http://sro.sussex.ac.uk/id/eprint/49149

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