Protein phosphatase 1 recruitment by Rif1 regulates DNA replication origin firing by counteracting DDK activity

Dave, Anoushka, Cooley, Carol, Garg, Mansi and Bianchi, Alessandro (2014) Protein phosphatase 1 recruitment by Rif1 regulates DNA replication origin firing by counteracting DDK activity. Cell Reports, 7 (1). pp. 53-61. ISSN 2211-1247

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Abstract

The eukaryotic genome is replicated according to a strict temporal program. Here, Bianchi and colleagues find that Rif1, a master regulator of the DNA replication program in yeast and mammals, exerts its effect on DNA replication origins by recruiting protein phosphatase 1 (PP1) to chromosomes. Rif1/PP1 counteracts the positive action of the DDK kinase on the replicative kinase MCM. In a final twist, kinase action on Rif1 is proposed to eventually release PP1 and allow origin firing.

Item Type: Article
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Subjects: R Medicine > R Medicine (General)
Depositing User: Jill Kirby
Date Deposited: 30 Jun 2014 14:16
Last Modified: 07 Mar 2017 10:22
URI: http://sro.sussex.ac.uk/id/eprint/49117

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Project NameSussex Project NumberFunderFunder Ref
Analysis of regulation telomerase action & telomore capping function by the telomeric complex (Fellow: Bianchi)G0129MRC-MEDICAL RESEARCH COUNCILG0701428