Pharmacogenetic analysis of GLCCI1 in three north European pediatric asthma populations with a reported use of inhaled corticosteroids

Vijverberg, Susanne J H, Tavendale, Roger, Leusink, Maarten, Koenderman, Leo, Raaijmakers, Jan AM, Postma, Dirkje S, Koppelman, Gerard H, Turner, Steve W, Mukhopadhyay, Somnath, Palmer, Colin N A and Maitland-van der Zee, Anke Hilse (2014) Pharmacogenetic analysis of GLCCI1 in three north European pediatric asthma populations with a reported use of inhaled corticosteroids. Pharmacogenomics, 15 (6). pp. 799-806. ISSN 1462-2416

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Abstract

GLCCI1 rs37972 has previously been associated with decreased lung function improvement upon treatment with inhaled corticosteroids (ICS) in asthmatics. Aim: To assess whether variation in rs37972 is associated with altered ICS efficacy in north European asthmatic children and young adults with a reported use of ICS. Patients & methods: rs37972 was genotyped in three cohort studies of asthmatic children with a reported use of ICS. As an indicator for asthma exacerbations, asthma-related hospital visits and oral corticosteroid use were studied. Asthma control was assessed using a questionnaire. Results: rs37972 T allele was not significantly associated with an increased risk of oral corticosteroid use (summary odds ratio: 1.20; 95% CI: 0.99-1.45), an increased risk of asthma-related hospital visits (summary odds ratio: 1.07; 95% CI: 0.89-1.29), uncontrolled symptoms (summary odds ratio: 1.01; 95% CI: 0.75-1.36) or higher ICS dosages (summary ;2: 0.01, 95% CI: -0.06-0.08). Conclusion: Variation in GLCCI1 rs37972 genotype does not seem to affect ICS efficacy in north European asthmatic children. Original submitted 26 November 2013; Revision submitted 13 February 2014.

Item Type: Article
Keywords: GLCCI1; asthma; children; corticosteroids; exacerbations; rs37972
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Subjects: R Medicine > RJ Pediatrics > RJ0047.3 Genetic aspects
Depositing User: Judy Keogh
Date Deposited: 25 Jun 2014 12:45
Last Modified: 29 Sep 2017 09:51
URI: http://sro.sussex.ac.uk/id/eprint/49066
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