Psychological morbidity associated with ovarian cancer screening: results from more than 23 000 women in the randomised trial of ovarian cancer screening (UKCTOCS)

Barrett, J, Jenkins, V, Farewell, V, Menon, U, Jacobs, I, Kilkerr, J, Ryan, A, Langridge, C, Fallowfield, L and UKCTOCS trialists, (2014) Psychological morbidity associated with ovarian cancer screening: results from more than 23 000 women in the randomised trial of ovarian cancer screening (UKCTOCS). BJOG: An International Journal of Obstetrics and Gynaecology, 121 (9). pp. 1071-1079. ISSN 1470-0328

Full text not available from this repository. (Request a copy)

Abstract

Objective To examine the psychological sequelae associated with abnormal screening in the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). Design Prospective, longitudinal randomised control trial. Setting Sixteen UKCTOCS centres. Sample Women aged 50–70 years randomised to annual multimodal screening, ultrasound screening or control groups. Methods Two groups were followed for 7 years: (1) a random sample (n = 1339), taken from all three study groups; and (2) an events sample (n = 22 035) of women with abnormal screens resulting in the need for repeat testing of either low or higher level intensity. Main outcome measures Patient-reported measures of anxiety (scores ranging from 20 to 80) and psychological morbidity. Results In the random sample the mean difference between anxiety scores after a repeat screening and those following an annual screening was 0.4 (95% CI −0.46, 1.27), and in the events sample it was 0.37 (95% CI 0.23, 0.51). The risk of psychological morbidity was only increased in the event sample for women requiring higher level repeat screening (OR 1.28; 95% CI 1.18, 1.39). The risk of psychological morbidity in women with ovarian cancer was higher at both 6 weeks (OR 16.2; 95% CI 9.19, 28.54) and 6 months (OR 3.32; 95% CI 1.91, 5.77) following surgery. Conclusions Screening does not appear to raise anxiety but psychological morbidity is elevated by more intense repeat testing following abnormal annual screens, and in women after surgical treatment for ovarian cancer.

Item Type: Article
Keywords: Anxiety ovarian cancer population screening programme psychological morbidity
Schools and Departments: Brighton and Sussex Medical School > Sussex Health Outcomes Research & Education in Cancer (SHORE-C)
Subjects: H Social Sciences > HA Statistics > HA154 Statistical data
R Medicine
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology Including cancer and carcinogens
Depositing User: Kathryn Monson
Date Deposited: 10 Jun 2014 13:53
Last Modified: 09 Mar 2015 15:12
URI: http://sro.sussex.ac.uk/id/eprint/48942
📧 Request an update
Project NameSussex Project NumberFunderFunder Ref
UKCTOCSG9901012Medical Research CouncilU105261167
UKCTOCSUnsetEve Appeal FoundationUnset