Clinical and pharmacogenomic implications of genetic variation in an Ethiopian population

Tekola-Ayele, Fasil, Adeyemo, Adebowale, Assefa, Abraham, Hailu, Elena, Finan, Christopher, Davey, Gail, Rotimi, Charles and Newport, Melanie (2015) Clinical and pharmacogenomic implications of genetic variation in an Ethiopian population. Pharmacogenomics Journal, 15 (1). pp. 101-108. ISSN 1470-269X

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Abstract

Africa is home to genetically diverse human populations. We compared the genetic structure of the Wolaita ethnic population from southern Ethiopia (WETH, n=120) with HapMap populations using genome-wide variants. We investigated allele frequencies of 443 clinically and pharmacogenomically relevant genetic variants in WETH compared to HapMap populations. We found that WETH were genetically most similar to the Kenya Maasai and least similar to the Japanese in HapMap. Variant alleles associated with increased risk of adverse reactions to drugs used for treating tuberculosis (rs1799929 and rs1495741 in NAT2), thromboembolism (rs7294, rs9923231 and rs9934438 in VKORC1), and HIV/AIDS and solid tumors (rs2242046 in SLC28A1) had significantly higher frequency in WETH compared to African ancestry HapMap populations. Our results illustrate that clinically relevant pharmacogenomic loci display allele frequency differences among African populations; therefore, drug dosage guidelines for diseases of global health relevance should be validated in genetically diverse African populations.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical Medicine
Brighton and Sussex Medical School > Global Health and Infection
Subjects: R Medicine > RB Pathology > RB151 Theories of disease. Etiology. Pathogenesis
Depositing User: Gail Davey
Date Deposited: 09 Jun 2014 13:37
Last Modified: 02 Aug 2017 16:18
URI: http://sro.sussex.ac.uk/id/eprint/48931

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