Newborns develop a Th1-type immune response to Mycobacterium bovis bacillus Calmette-Guérin vaccination

Marchant, Arnaud, Goetghebuer, Tessa, Ota, Martin O, Wolfe, Ingrid, Ceesay, Serign J, De Groote, Donat, Corrah, Tumani, Bennett, Steve, Wheeler, Jeremy, Huygen, Kris, Aaby, Peter, McAdam, Keith P J W and Newport, Melanie J (1999) Newborns develop a Th1-type immune response to Mycobacterium bovis bacillus Calmette-Guérin vaccination. Journal of Immunology, 163 (4). pp. 2249-2255. ISSN 0022-1767

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Abstract

Data obtained in animals indicate that neonatal immune responses are biased toward Th2. This could reduce the efficacy of vaccines against viral and mycobacterial diseases. The ability of human newborns to develop a Th1 immune response upon immunization has not been studied. Since the vaccine Mycobacterium bovis bacillus Calmette-Guérin (BCG) triggers a Th1-type response in adults, we investigated whether it induces a similar response in newborns and whether age at vaccination influences immunogenicity. We found that BCG vaccination at birth induces a memory Th1-type response of similar magnitude to that when given later in life. This study demonstrates that human newborns can be immunized against pathogens controlled by a Th1 immune response.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Global Health and Infection
Subjects: R Medicine > RC Internal medicine > RC0251 Constitutional diseases (General)
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Depositing User: pam Thompson
Date Deposited: 08 May 2014 13:28
Last Modified: 04 Aug 2017 14:33
URI: http://sro.sussex.ac.uk/id/eprint/48402
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