Neonatal bacillus Calmette-Guérin vaccination induces adult-like IFN-gamma production by CD4+ T lymphocytes

Vekemans, Johan, Amedei, Amedeo, Ota, Martin O, D'Elios, Mario M, Goetghebuer, Tessa, Ismaili, Jamila, Newport, Melanie J, Del Prete, Gianfranco, Goldman, Michel, McAdam, Keith P W J and Marchant, Arnaud (2001) Neonatal bacillus Calmette-Guérin vaccination induces adult-like IFN-gamma production by CD4+ T lymphocytes. European Journal of Immunology, 31 (5). pp. 1531-1535. ISSN 0014-2980

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Abstract

The immaturity of the neonatal immune system in mice is associated with defective IFN-gamma production and Th2-biased immune responses. In this study, infants vaccinated at birth with BCG produced similar concentrations of IFN-gamma in response to PPD and showed similar frequencies of IFN-gamma-producing lymphocytes as compared to immune adults. Infants and adults produced only low concentrations of IL-4 and IL-5. CD4+ T lymphocytes were the main source of IFN-gamma. Similar proportions of Th1 and Th0 PPD-specific T cell clones were observed in infants and adults. This study demonstrates that the human neonatal immune response to BCG is not biased towards Th2 and is characterized by the predominant production of IFN-gamma by CD4+ T lymphocytes.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Primary Care and Public Health
Brighton and Sussex Medical School > Global Health and Infection
Subjects: R Medicine > RC Internal medicine > RC0251 Constitutional diseases (General)
Depositing User: pam Thompson
Date Deposited: 08 May 2014 17:31
Last Modified: 21 Sep 2017 13:42
URI: http://sro.sussex.ac.uk/id/eprint/48400
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