Polymorphism in NOD2, Crohn's disease, and susceptibility to pulmonary tuberculosis

Stockton, Jemima C, Howson, Joanna M M, Awomoyi, Agnes A, McAdam, Keith P, Blackwell, Jenefer M and Newport, Melanie J (2004) Polymorphism in NOD2, Crohn's disease, and susceptibility to pulmonary tuberculosis. FEMS Immunology and Medical Microbiology, 41 (2). pp. 157-160. ISSN 0928-8244

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Abstract

The nucleotide oligomerization binding domain 2 gene (NOD2) encodes an intracellular receptor for bacterial components, which is expressed in monocytes and is associated with Crohn's Disease (CD). This finding, along with epidemiological evidence, supports a role for infection in the pathogenesis of CD. Speculation that mycobacteria are involved in CD led us to investigate NOD2 in susceptibility to tuberculosis (TB), a global public health problem caused by Mycobacterium tuberculosis. CD-associated NOD2 variants were absent in a case-control study of 640 Gambians, where CD is rare. Novel NOD2 promoter polymorphisms were identified but showed no association with TB in this African population sample.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Primary Care and Public Health
Subjects: R Medicine > RC Internal medicine > RC0251 Constitutional diseases (General)
R Medicine > RC Internal medicine > RC0306 Tuberculosis
Depositing User: pam Thompson
Date Deposited: 09 May 2014 14:04
Last Modified: 09 May 2014 14:04
URI: http://sro.sussex.ac.uk/id/eprint/48386
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