Molecular diagnosis of Fusobacterium necrophorum infection (Lemierre's syndrome)

Aliyu, S H, Yong, P F K, Newport, M J, Zhang, H, Marriott, R K, Curran, M D and Ludlam, H (2005) Molecular diagnosis of Fusobacterium necrophorum infection (Lemierre's syndrome). European Journal of Clinical Microbiology and Infectious Diseases, 24 (3). pp. 226-229. ISSN 0934-9723

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Abstract

Presented here is the case of a 27-year-old male with atypical features of Lemierre's syndrome in which a definitive diagnosis was achieved using molecular methods. While routine investigations, including bacterial cultures, were unhelpful, two real-time PCR assays demonstrated Fusobacterium necrophorum-specific DNA in aspirates from brain and renal abscesses. This is the first report demonstrating that a laboratory diagnosis can be made using molecular methods in suspected cases of Lemierre's syndrome. Use of these methods can thus resolve diagnostic confusion, prevent unnecessary investigation, and direct specific antimicrobial treatment.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Primary Care and Public Health
Brighton and Sussex Medical School > Global Health and Infection
Subjects: R Medicine > RC Internal medicine > RC0251 Constitutional diseases (General)
Depositing User: pam Thompson
Date Deposited: 09 May 2014 12:15
Last Modified: 21 Sep 2017 13:33
URI: http://sro.sussex.ac.uk/id/eprint/48385
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