Dissociation between tuberculin skin test and in vitro IFN-gamma responses following neonatal BCG vaccination

Ota, Martin O C, Goetghebuer, Tessa, Vekemans, Johan, Okoko, Brown J, Newport, Melanie J, McAdam, Keith P W J and Marchant, Arnaud (2006) Dissociation between tuberculin skin test and in vitro IFN-gamma responses following neonatal BCG vaccination. Journal of Tropical Pediatrics, 52 (2). pp. 136-140. ISSN 0142-6338

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Abstract

The in vitro IFN-gamma response to tuberculin was recently proposed as a correlate of vaccine-induced immunity to tuberculosis. IFN-gamma also plays a central role in the tuberculin skin test (TST), commonly used as a marker of mycobacterial infection. However, the use of TST as a marker of immunity to tuberculosis is limited for reasons ascribed mainly to interference by environmental mycobacteria. We prospectively investigated the relationship between the TST and cytokine responses to BCG in early infancy, a cohort with relatively low exposure to environmental mycobacteria. Neonatal BCG vaccination induced positive TST responses and predominant IFN-gamma responses to tuberculin in most newborns. However, the production of IFN-gamma, IL-5 and IL-13 was similar in TST responders and non-responders, and there was no significant correlation between the size of TST response and cytokine production. These results indicate that the IFN-gamma assay provides different information than TST in BCG-vaccinated newborns and could be a better marker of vaccine-induced immunity.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Brighton and Sussex Medical School > Global Health and Infection
Subjects: R Medicine > RC Internal medicine > RC0251 Constitutional diseases (General)
R Medicine > RC Internal medicine > RC0306 Tuberculosis
Depositing User: pam Thompson
Date Deposited: 12 May 2014 12:41
Last Modified: 21 Sep 2017 11:58
URI: http://sro.sussex.ac.uk/id/eprint/48377
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