Population differences in immune responses to Bacille Calmette-Guérin vaccination in infancy

Lalor, Maeve K, Ben-Smith, Anne, Gorak-Stolinska, Patricia, Weir, Rosemary E, Floyd, Sian, Blitz, Rose, Mvula, Hazzie, Newport, Melanie J, Branson, Keith, McGrath, Nuala, Crampin, Amelia C, Fine, Paul E M and Dockrell, Hazel M (2009) Population differences in immune responses to Bacille Calmette-Guérin vaccination in infancy. Journal of Infectious Diseases, 199 (6). pp. 795-800. ISSN 0022-1899

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Abstract

Bacille Calmette-Guérin (BCG) vaccination induces a marked increase in the interferon (IFN)-gamma response to Mycobacterium tuberculosis purified protein derivative (Mtb PPD) in UK adolescents, but not in Malawian adolescents. We hypothesized that Mtb PPD-induced IFN-gamma after BCG vaccination would be similar in infants from these 2 countries. Infants were vaccinated with BCG during the first 3-13 weeks of life. Three months after BCG vaccination, 51 (100%) of 51 UK infants had an IFN-gamma response to Mtb PPD, compared to 41 (53%) of 78 of Malawian infants, in whom responses varied according to their season of birth. We conclude that population differences in immune responses after BCG vaccination are observed among infants, as well as among young adults.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Primary Care and Public Health
Brighton and Sussex Medical School > Global Health and Infection
Subjects: R Medicine > RC Internal medicine > RC0031 Internal medicine. Practice of medicine
R Medicine > RC Internal medicine > RC0251 Constitutional diseases (General)
Depositing User: pam Thompson
Date Deposited: 12 May 2014 11:28
Last Modified: 21 Sep 2017 11:51
URI: http://sro.sussex.ac.uk/id/eprint/48368
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