The neural substrates of the warning effect: a functional magnetic resonance imaging study

Yoshida, Yumiko, Tanabe, Hiroki C, Hayashi, Masamichi J, Kawamichi, Hiroaki, Kochiyama, Takanori and Sadato, Norihiro (2013) The neural substrates of the warning effect: a functional magnetic resonance imaging study. Neuroscience Research, 76 (4). pp. 230-239. ISSN 0168-0102

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Abstract

To test the hypothesis the warning effect is mediated by the top-down attentional modulation of the motor system, we conducted functional MRI using a Go/No-Go task with visual and auditory warning stimuli. For aurally-warned, visually-prompted trials, the auditory warning stimulus was presented for 1500ms, during which visual cues were presented that prompted either Go or No-Go responses. The same format was used for visually-warned, aurally-prompted trials. Both auditory and visual warning cues shortened the reaction time for the Go trials. The warning cues activated the right-lateralized parieto-frontal top-down attentional network, and motor cortical areas including the pre-supplementary motor area (pre-SMA), the bilateral dorsal premotor cortex, and the left primary motor cortex (M1). The warning-related activation of the pre-SMA matched the difference between its activation by Go-with-warning and by Go-without-warning. Thus, the pre-SMA was primed by the warning cue. The same pre-SMA priming effect was observed for the No-Go cue-related activation, consistent with its role in movement preparation and selection. Similar but less prominent Go cue-related priming was observed in the M1. Thus, the warning effect represents the pre-potentiation of the motor control pathway by the top-down attentional system, from the selection and preparation of the movement to its execution.

Item Type: Article
Schools and Departments: School of Psychology > Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology > BF0180 Experimental psychology
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
Depositing User: Dr Masamichi Hayashi
Date Deposited: 10 Mar 2014 08:10
Last Modified: 10 Mar 2014 08:10
URI: http://sro.sussex.ac.uk/id/eprint/47801
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