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Replication stress and genome rearrangements: lessons from yeast models

journal contribution
posted on 2023-06-08, 16:46 authored by Sarah Lambert, Antony CarrAntony Carr
Replication failures induced by replication fork barriers (RFBs) or global replication stress generate many of the chromosome rearrangement(CR)observed in humangenomic disorders and cancer. RFBs have multiple causes and cells protect themselves from the consequences of RFBs using three general strategies: preventing expression of RFB activity, stabilising the arrested replisome and, in the case of replisome failure, shielding the fork DNA to allow rebuilding of the replisome. Yeast models provide powerful tools to understand the cellular response to RFBs, delineate pathways that suppress genome instability and de?ne mechanisms by which CRs occur when these fail. Recent progress has identi?ed key features underlying RFBs activity and is beginning to uncover the DNA dynamics that bring about genome instability.

History

Publication status

  • Published

File Version

  • Published version

Journal

Current Opinion in Genetics and Development

ISSN

0959-437X

Publisher

Elsevier

Issue

2

Volume

23

Page range

132-139

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2014-02-26

First Compliant Deposit (FCD) Date

2014-02-25

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