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Serious fatal and nonfatal non-AIDS-defining illnesses in Europe
journal contribution
posted on 2023-06-08, 16:43 authored by Amanda Mocroft, Peter Reiss, Jacek Gasiorowski, Bruno Ledergerber, Justyna Kowalska, Antonio Chiesi, Jose Gatell, Aza Rakhmanova, Margaret Johnson, Ole Kirk, Jens Lundgren, The EuroSIDA Study Group, Martin FisherBACKGROUND Little is known about the incidence and risk factors for serious non-AIDS-defining events. METHODS The incidence of non-AIDS events (malignancies, end-stage renal disease, liver failure, pancreatitis, cardiovascular disease), and AIDS after January 1, 2001, was calculated; Poisson regression was used to investigate factors associated with non-AIDS and AIDS. RESULTS Among 12,844 patients, 1058 were diagnosed with a non-AIDS event [incidence 1.77 per 100 person-years of follow-up; 95% confidence interval (CI): 1.66 to 1.87]; 462 patients (43.7%) died. The incidence of AIDS (1025 diagnoses; 339 deaths, 33.1%) was 1.72 per 100 person-years of follow-up (1.61 to 1.83). After adjustment, older age [incidence rate ratio (IRR): 1.71 per 10 years older, 95% CI: 1.60 to 1.83], diabetes (IRR: 1.49, 95% CI: 1.22 to 1.82) and hypertension (IRR: 1.63, 95% CI: 1.43 to 1.87) were associated with non-AIDS events. Compared with patients without an event, there was a 4-fold increased risk of death after an AIDS event (relative hazard: 4.14; 95% CI 3.47 to 4.94) and almost a 7-fold increased risk of death after a non-AIDS event (relative hazard: 6.72; 95% CI: 5.61 to 8.05). CONCLUSIONS Non-AIDS events were common in the combination antiretroviral therapy era and associated with considerably mortality. Evidence on the impact of modifying immunodeficiency and lifestyle-related factors on the risk of non-AIDS events in HIV-infected persons is an important but unmet research need.
History
Publication status
- Published
Journal
Journal of Acquired Immune Deficiency SyndromesISSN
1525-4135Publisher
Lippincott, Williams & WilkinsExternal DOI
Issue
2Volume
55Page range
262-270Department affiliated with
- BSMS Publications
Notes
Martin Fisher is not a named author of this article but is a member of the EuroSIDA study group.Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2014-04-07Usage metrics
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