Impaired renal function and biomarkers of vascular disease in Alzheimer’s disease

Richardson, Cassandra, Nilforooshan, Ramin, Gard, Paul R, Weaving, Gary and Tabet, Naji (2014) Impaired renal function and biomarkers of vascular disease in Alzheimer’s disease. Current Alzheimer Research, 11 (3). pp. 253-258. ISSN 1567-2050

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Abstract

Renal disease is a risk factor for vascular diseases and for dementia, and renal insufficiency can be a feature of
Alzheimer’s disease (AD). Evidence has suggested that vascular mechanisms mediate the link between renal disease and dementia. Our study sought to test this hypothesis by examining renal and vascular functioning in AD by investigating estimated glomerular filtration rates (eGFR), calculated from serum creatinine concentrations, and established biomarkers of vascular functioning, asymmetrical dimethylarginine (ADMA) and plasma homocysteine (Hcy), in individuals with mild to moderate AD (n = 34) and a group of older adult controls (n = 34). We found significantly reduced eGFR, indicative of impaired renal functioning, in individuals with AD (M = 62.9, SD = 15.2) compared with controls (M = 73.6, SD = 11.8). However, concentrations of ADMA and Hcy did not differ between patient and control groups (ADMA: M = 0.47; M =
0.50; Hcy: M = 17.2; M = 14.9; patients and controls). The criteria for a mediation analysis were not met, as concentrations of ADMA and Hcy did not predict AD, indicating that these biomarkers of vascular functioning did not mediate a relationship between renal functioning and AD. This study indicated that renal insufficiency may independently contribute to AD pathology, and other vascular mechanisms may influence a relationship between renal impairment and AD.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical Medicine
Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
Depositing User: Cassandra Richardson
Date Deposited: 12 Feb 2014 15:17
Last Modified: 27 Jul 2017 16:56
URI: http://sro.sussex.ac.uk/id/eprint/47525

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