Antihypertensives, angiotensin, glucose and Alzheimer’s disease

Nelson, Lucy, Tabet, Naji, Richardson, Cassie and Gard, Paul (2013) Antihypertensives, angiotensin, glucose and Alzheimer’s disease. Expert Review of Neurotherapeutics, 13 (5). pp. 477-482. ISSN 1473-7175

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Abstract

Evidence supporting a link between vascular disorders such as hypertension and Alzheimer’s disease (AD) is increasing. Population studies have suggested an association between
hypertension and an increased risk of developing AD. A potential role for antihypertensive medications in the management of cognitive disorders has also been suggested, although findings are mixed. However, it is of interest that evidence is now leaning towards the possibility
that some of these antihypertensive medications may improve cognition independent of their blood pressure lowering effects. Many of these drugs cross the blood–brain barrier and may influence neurotransmitters involved in cognition. Increasing knowledge of the actions of antihypertensives in the brain and the vascular system could lead to better treatment and/or prevention options for AD.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical Medicine
Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > RM Therapeutics. Pharmacology
Depositing User: Cassandra Richardson
Date Deposited: 12 Feb 2014 15:06
Last Modified: 13 Aug 2017 21:20
URI: http://sro.sussex.ac.uk/id/eprint/47522

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