DNA_Strand_Break_Repair_and_Neurodegeneration_-_revised.pdf (931.77 kB)
DNA strand break repair and neurodegeneration.
journal contribution
posted on 2023-06-08, 16:37 authored by Stuart L Rulten, Keith CaldecottKeith CaldecottA number of DNA repair disorders are known to cause neurological problems. These disorders can be broadly characterised into early developmental, mid-to-late developmental or progressive. The exact developmental processes that are affected can influence disease pathology, with symptoms ranging from early embryonic lethality to late-onset ataxia. The category these diseases belong to depends on the frequency of lesions arising in the brain, the role of the defective repair pathway, and the nature of the mutation within the patient. Using observations from patients and transgenic mice, we discuss the importance of double strand break repair during neuroprogenitor proliferation and brain development and the repair of single stranded lesions in neuronal function and maintenance.
History
Publication status
- Published
File Version
- Accepted version
Journal
DNA repairISSN
1568-7856Publisher
ElsevierExternal DOI
Issue
8Volume
12Page range
558-567Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2015-09-18First Open Access (FOA) Date
2015-09-18First Compliant Deposit (FCD) Date
2014-01-14Usage metrics
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