Arterial stiffness evaluation in HIV-positive patients: a multicenter matched control study

Ferraioli, Giovanna, Tinelli, Carmine, Maggi, Paolo, Gervasoni, Cristina, Grima, Pierfrancesco, Viskovic, Klaudija, Carerj, Scipione, Filice, Gaetano, Filice, Carlo, Fisher, Martin and and the Arterial Stiffness Evaluation in HIV-Infected Subjects S, (2011) Arterial stiffness evaluation in HIV-positive patients: a multicenter matched control study. American Journal of Roentgenology, 197 (5). pp. 1258-1262. ISSN 1546-3141

Full text not available from this repository.

Abstract

OBJECTIVE

The purpose of this article is to assess the differences, if any, in the values of carotid artery stiffness parameters between HIV-infected subjects without known cardiovascular disease (CVD) or carotid artery plaques and HIV-uninfected control subjects matched for sex, age, body mass index, and other CVD risk factors (i.e., hypertension, hypercholesterolemia, diabetes, and cigarette smoking). Arterial stiffness is emerging as a predictor of CVD risk. By recording the blood pressure, an automated echo-tracking system implemented in ultrasound equipment allows evaluation of arterial stiffness.

SUBJECTS AND METHODS

Fifty-four HIV-infected patients without a history of CVD were closely matched for sex, age, body mass index, and CVD risk factors to 54 HIV-uninfected control subjects on an individual basis. Ultrasound studies of carotid artery stiffness parameters were performed using ultrasound equipment with a linear broadband high-frequency transducer. Carotid intima-media thickness was also measured. Repeatability between operators was assessed. Nonparametric Mann-Whitney U test, chi-square statistics, Fisher exact test, Pearson correlation coefficient, and intraclass correlation coefficient were used for statistical analysis. A p value less than 0.05 was considered statistically significant.

RESULTS

Except for arterial compliance in HIV-infected subjects, arterial stiffness parameters were correlated with age in both groups. Compared with matched control subjects, HIV-infected subjects showed lower arterial compliance parameter values (0.95 [interquartile range, 0.78-1.23] vs 0.76 [interquartile range, 0.62-1.00]; p = 0.0009), whereas other parameters were similar. Repeatability between operators was good.

CONCLUSION

HIV-infected subjects have an arterial compliance significantly lower than that of control subjects. The impairment of carotid artery distensibility may contribute to subclinical atherosclerosis.

Item Type: Article
Additional Information: Martin Fisher is part of the Arterial Stiffness Evaluation in HIV-Infected Subjects Study Group and not one of the principal authors
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine > RA0643 Communicable diseases and public health > RA0644 Individual diseases or groups of diseases, A-Z > RA0644.A25 AIDS. HIV infections
Related URLs:
Depositing User: Ellen Thomas
Date Deposited: 23 Dec 2013 13:25
Last Modified: 23 Dec 2013 13:25
URI: http://sro.sussex.ac.uk/id/eprint/47280
📧 Request an update