File(s) not publicly available
Memantine affects cognitive flexibility in the Morris water maze
journal contribution
posted on 2023-06-08, 16:23 authored by Bechara J Saab, Ruxandra Luca, Wing B Yuen, Adam M P Saab, John C RoderAlzheimer's disease (AD) is multi-factorial mental disorder characterized by a copious array of congruent features cumulating in disrupted memory and dysthymia. Though the mechanism remains elusive, the highly unspecific pharmaceutical, memantine, provides modest benefits for patients with moderate-to-severe AD. A greater understanding of how memantine affects cognitive function promises to facilitate the search for better therapeutics. We therefore examined cognitive flexibility of mice following 5 and 10 mg/kg memantine administration using a platform re-location water maze. Strikingly, subjects receiving memantine demonstrated memory impairment relative to controls when re-trained off drug, revealing a novel and unusual disruption of cognitive flexibility.
History
Publication status
- Published
Journal
Journal of Alzheimer's DiseaseISSN
1387-2877Publisher
IOS PressExternal DOI
Issue
3Volume
27Page range
477-482Department affiliated with
- Business and Management Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2013-11-22Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC